<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="UTF-8">
  <meta name="viewport" content="width=device-width, initial-scale=1.0">
  <meta name="aspect-ratio" content="4:3">
  <style>
    * {
      box-sizing: border-box;
      margin: 0;
      padding: 0;
      font-family: system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, sans-serif;
    }

    body {
      width: 100%;
      background: #f8fafc;
      color: #1e2945;
      display: flex;
      flex-direction: column;
      align-items: center;
      justify-content: center;
      padding: 12px;
    }

    .diagram-wrap {
      width: 100%;
      max-width: 580px;
      display: flex;
      flex-direction: column;
      gap: 12px;
    }

    /* Interactive button selector */
    .btn-row {
      display: flex;
      gap: 6px;
      justify-content: center;
      flex-wrap: wrap;
    }

    .force-btn {
      background: #ffffff;
      border: 1px solid #cbd5e1;
      border-radius: 6px;
      padding: 5px 10px;
      font-size: 13px;
      font-weight: 600;
      color: #475569;
      cursor: pointer;
      box-shadow: 0 1px 2px rgba(0, 0, 0, 0.05);
      transition: background-color 0.2s ease, border-color 0.2s ease, color 0.2s ease;
    }

    .force-btn.active {
      border-color: #22b7ff;
      background: #e0f2fe;
      color: #0369a1;
    }

    /* SVG viewport */
    .svg-container {
      width: 100%;
      background: #ffffff;
      border: 1px solid #e2e8f0;
      border-radius: 12px;
      overflow: hidden;
    }

    svg {
      display: block;
      width: 100%;
      height: auto;
    }

    /* Text & Arrow styles */
    .label-title {
      font-size: 13px;
      font-weight: 700;
      fill: #1e2945;
    }

    .label-sub {
      font-size: 11px;
      font-weight: 600;
      fill: #64748b;
    }

    .val-text {
      font-size: 12px;
      font-weight: 700;
    }

    .val-green { fill: #15803d; }
    .val-red { fill: #b91c1c; }
    .val-gray { fill: #94a3b8; }
    .val-net { fill: #0284c7; }

    .force-elem {
      transition: opacity 0.3s ease;
    }

    .dimmed {
      opacity: 0.2;
    }

    /* Net balance bar */
    .net-card {
      background: #ffffff;
      border: 1px solid #e2e8f0;
      border-radius: 10px;
      padding: 10px 14px;
      display: flex;
      align-items: center;
      justify-content: space-between;
      flex-wrap: wrap;
      gap: 8px;
    }

    .net-math {
      display: flex;
      align-items: center;
      gap: 6px;
      font-size: 14px;
      font-weight: 600;
    }

    .pill {
      display: inline-block;
      padding: 2px 8px;
      border-radius: 4px;
      font-size: 12px;
      font-weight: 700;
    }

    .pill-green { background: #dcfce7; color: #166534; }
    .pill-red { background: #fee2e2; color: #991b1b; }
    .pill-blue { background: #e0f2fe; color: #075985; }
  </style>
</head>
<body>

<div class="diagram-wrap">
  <div class="btn-row">
    <button class="force-btn active" data-force="all">All Forces</button>
    <button class="force-btn" data-force="pgc">P<sub>GC</sub> (+55)</button>
    <button class="force-btn" data-force="pigc">π<sub>GC</sub> (-30)</button>
    <button class="force-btn" data-force="pbs">P<sub>BS</sub> (-15)</button>
    <button class="force-btn" data-force="pibs">π<sub>BS</sub> (0)</button>
  </div>

  <div class="svg-container">
    <svg viewBox="0 0 540 240" width="100%" height="100%">
      <defs>
        
        <marker id="arrow-green" markerWidth="6" markerHeight="6" refX="5" refY="3" orient="auto">
          <path d="M0,0 L6,3 L0,6 Z" fill="#16a34a" />
        </marker>
        <marker id="arrow-red" markerWidth="6" markerHeight="6" refX="5" refY="3" orient="auto">
          <path d="M0,0 L6,3 L0,6 Z" fill="#dc2626" />
        </marker>
        <marker id="arrow-net" markerWidth="7" markerHeight="7" refX="6" refY="3.5" orient="auto">
          <path d="M0,0 L7,3.5 L0,7 Z" fill="#0284c7" />
        </marker>
      </defs>

      
      <rect x="0" y="0" width="540" height="240" fill="#f1f5f9" />
      <text x="400" y="32" class="label-title">Bowman's Space</text>
      <text x="400" y="48" class="label-sub">Capsular Fluid</text>

      
      <path d="M 0,0 L 220,0 L 220,240 L 0,240 Z" fill="#fee2e2" opacity="0.65" />
      
      
      <line x1="220" y1="0" x2="220" y2="240" stroke="#ef4444" stroke-width="4" stroke-dasharray="8 6" />
      
      <text x="24" y="32" class="label-title">Glomerular Capillary</text>
      <text x="24" y="48" class="label-sub">Blood Plasma</text>

      
      <g id="force-pgc" class="force-elem">
        <line x1="160" y1="90" x2="330" y2="90" stroke="#16a34a" stroke-width="7" marker-end="url(#arrow-green)" stroke-linecap="round" />
        <text x="340" y="86" class="val-text val-green">P<tspan baseline-shift="sub" font-size="9">GC</tspan> = +55 mmHg</text>
        <text x="340" y="100" class="label-sub">Hydrostatic (Favors)</text>
      </g>

      
      <g id="force-pigc" class="force-elem">
        <line x1="280" y1="140" x2="180" y2="140" stroke="#dc2626" stroke-width="5" marker-end="url(#arrow-red)" stroke-linecap="round" />
        <text x="290" y="136" class="val-text val-red">π<tspan baseline-shift="sub" font-size="9">GC</tspan> = -30 mmHg</text>
        <text x="290" y="150" class="label-sub">Colloid Oncotic (Opposes)</text>
      </g>

      
      <g id="force-pbs" class="force-elem">
        <line x1="260" y1="185" x2="200" y2="185" stroke="#dc2626" stroke-width="3.5" marker-end="url(#arrow-red)" stroke-linecap="round" />
        <text x="270" y="181" class="val-text val-red">P<tspan baseline-shift="sub" font-size="9">BS</tspan> = -15 mmHg</text>
        <text x="270" y="195" class="label-sub">Capsular Hydrostatic (Opposes)</text>
      </g>

      
      <g id="force-pibs" class="force-elem">
        <circle cx="240" cy="222" r="3.5" fill="#94a3b8" />
        <text x="252" y="226" class="val-text val-gray">π<tspan baseline-shift="sub" font-size="9">BS</tspan> ≈ 0 mmHg (No Protein)</text>
      </g>
    </svg>
  </div>

  
  <div class="net-card">
    <div class="net-math">
      <span class="pill pill-green">+55</span>
      <span>−</span>
      <span class="pill pill-red">30</span>
      <span>−</span>
      <span class="pill pill-red">15</span>
      <span>=</span>
      <span class="pill pill-blue">+10 mmHg</span>
    </div>
    <div style="font-size: 13px; font-weight: 700; color: #0284c7; display: flex; align-items: center; gap: 4px;">
      <span>Net Filtration Outward</span> →
    </div>
  </div>
</div>

<script>
  const buttons = document.querySelectorAll('.force-btn');
  const forces = {
    pgc: document.getElementById('force-pgc'),
    pigc: document.getElementById('force-pigc'),
    pbs: document.getElementById('force-pbs'),
    pibs: document.getElementById('force-pibs')
  };

  buttons.forEach(btn => {
    btn.addEventListener('click', () => {
      buttons.forEach(b => b.classList.remove('active'));
      btn.classList.add('active');

      const target = btn.getAttribute('data-force');
      if (target === 'all') {
        Object.values(forces).forEach(el => el.classList.remove('dimmed'));
      } else {
        Object.entries(forces).forEach(([key, el]) => {
          if (key === target) {
            el.classList.remove('dimmed');
          } else {
            el.classList.add('dimmed');
          }
        });
      }
    });
  });
</script>

</body>
</html>

Nephron Anatomy and Glomerular Ultrafiltration Dynamics

<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="UTF-8">
  <meta name="viewport" content="width=device-width, initial-scale=1.0">
  <style>
    * {
      box-sizing: border-box;
      margin: 0;
      padding: 0;
    }
    body {
      font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, sans-serif;
      background: #f8fafc;
      color: #0f172a;
      padding: 12px;
      display: flex;
      flex-direction: column;
      align-items: center;
      justify-content: space-between;
      min-height: 100vh;
      overflow-x: hidden;
    }
    .stepper-nav {
      display: flex;
      gap: 8px;
      width: 100%;
      max-width: 480px;
      margin-bottom: 6px;
    }
    .step-btn {
      flex: 1;
      padding: 7px 4px;
      border: 1.5px solid #cbd5e1;
      background: #ffffff;
      border-radius: 6px;
      font-size: 12px;
      font-weight: 700;
      color: #475569;
      cursor: pointer;
      text-align: center;
      transition: background-color 0.2s ease, border-color 0.2s ease, color 0.2s ease;
    }
    .step-btn.active {
      background: #0284c7;
      color: #ffffff;
      border-color: #0284c7;
      box-shadow: 0 2px 4px rgba(2, 132, 199, 0.25);
    }
    .flow-container {
      display: flex;
      flex-direction: column;
      align-items: center;
      gap: 6px;
      width: 100%;
      max-width: 480px;
      flex: 1;
      justify-content: center;
    }
    .calc-card {
      width: 100%;
      background: #ffffff;
      border: 1.5px solid #cbd5e1;
      border-radius: 10px;
      padding: 10px 14px;
      transition: border-color 0.25s ease, box-shadow 0.25s ease, background-color 0.25s ease;
      opacity: 0.88;
      cursor: pointer;
    }
    .calc-card.active {
      opacity: 1;
      border: 2px solid #0284c7;
      background: #ffffff;
      box-shadow: 0 4px 14px rgba(2, 132, 199, 0.16);
    }
    .card-header {
      display: flex;
      align-items: center;
      justify-content: space-between;
      margin-bottom: 6px;
    }
    .card-tag {
      font-size: 11px;
      font-weight: 800;
      text-transform: uppercase;
      letter-spacing: 0.5px;
      padding: 3px 8px;
      border-radius: 12px;
    }
    .tag-blue {
      color: #0369a1;
      background: #e0f2fe;
      border: 1px solid #bae6fd;
    }
    .tag-teal {
      color: #0f766e;
      background: #ccfbf1;
      border: 1px solid #99f6e4;
    }
    .tag-amber {
      color: #92400e;
      background: #fef3c7;
      border: 1px solid #fde68a;
    }
    .formula-row {
      font-family: ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, monospace;
      font-size: 13px;
      font-weight: 600;
      color: #334155;
      margin-bottom: 4px;
    }
    .math-row {
      display: flex;
      align-items: center;
      justify-content: space-between;
      flex-wrap: wrap;
      gap: 6px;
    }
    .sub-calc {
      font-size: 14px;
      font-weight: 600;
      color: #1e293b;
    }
    .result-badge {
      font-size: 13px;
      font-weight: 800;
      padding: 4px 10px;
      border-radius: 6px;
      background: #dcfce7;
      color: #14532d;
      border: 1.5px solid #86efac;
      white-space: nowrap;
    }
    .result-badge.blue {
      background: #e0f2fe;
      color: #0369a1;
      border-color: #7dd3fc;
    }
    .result-badge.amber {
      background: #fef3c7;
      color: #92400e;
      border-color: #fcd34d;
    }
    .calc-card.active .result-badge {
      box-shadow: 0 1px 3px rgba(0, 0, 0, 0.08);
    }
    .connector {
      font-size: 15px;
      line-height: 1;
      color: #0284c7;
      font-weight: 900;
      opacity: 0.85;
    }
    .controls {
      display: flex;
      align-items: center;
      gap: 8px;
      margin-top: 6px;
    }
    .play-btn {
      background: #0f172a;
      color: #ffffff;
      border: none;
      border-radius: 6px;
      padding: 6px 14px;
      font-size: 12px;
      font-weight: 700;
      cursor: pointer;
      transition: background 0.2s ease;
    }
    .play-btn:hover {
      background: #1e293b;
    }

    @media (max-width: 380px) {
      .formula-row {
        font-size: 12px;
      }
      .sub-calc {
        font-size: 13px;
      }
      .result-badge {
        font-size: 12px;
        padding: 3px 8px;
      }
      .calc-card {
        padding: 8px 10px;
      }
    }
  </style>
</head>
<body>

  <div class="stepper-nav">
    <button class="step-btn active" onclick="setStep(0)">1. NFP</button>
    <button class="step-btn" onclick="setStep(1)">2. GFR</button>
    <button class="step-btn" onclick="setStep(2)">3. Daily</button>
  </div>

  <div class="flow-container">
    
    <div class="calc-card active" id="card-0" onclick="setStep(0)">
      <div class="card-header">
        <span class="card-tag tag-blue">Step 1 &bull; Starling Net Pressure</span>
      </div>
      <div class="formula-row">
        NFP = P<sub>GC</sub> &minus; (P<sub>BS</sub> + &pi;<sub>GC</sub>)
      </div>
      <div class="math-row">
        <span class="sub-calc">55 &minus; (15 + 30) =</span>
        <span class="result-badge">+10 mmHg</span>
      </div>
    </div>

    <div class="connector">&darr;</div>

    
    <div class="calc-card" id="card-1" onclick="setStep(1)">
      <div class="card-header">
        <span class="card-tag tag-teal">Step 2 &bull; Filtration Rate</span>
      </div>
      <div class="formula-row">
        GFR = K<sub>f</sub> &times; NFP
      </div>
      <div class="math-row">
        <span class="sub-calc">12.5 &times; <strong>10</strong> =</span>
        <span class="result-badge blue">125 mL/min</span>
      </div>
    </div>

    <div class="connector">&darr;</div>

    
    <div class="calc-card" id="card-2" onclick="setStep(2)">
      <div class="card-header">
        <span class="card-tag tag-amber">Step 3 &bull; 24-Hour Total</span>
      </div>
      <div class="formula-row">
        Volume = GFR &times; 1,440 min/day
      </div>
      <div class="math-row">
        <span class="sub-calc"><strong>125</strong> &times; 1,440 =</span>
        <span class="result-badge amber">180 Liters/day</span>
      </div>
    </div>
  </div>

  <div class="controls">
    <button class="play-btn" id="playBtn" onclick="togglePlay()">⏸ Pause</button>
  </div>

  <script>
    let currentStep = 0;
    let isPlaying = true;
    let timer = null;

    function updateUI() {
      for (let i = 0; i < 3; i++) {
        document.querySelectorAll('.step-btn')[i].classList.toggle('active', i === currentStep);
        document.getElementById(`card-${i}`).classList.toggle('active', i === currentStep);
      }
    }

    function setStep(idx) {
      currentStep = idx;
      updateUI();
    }

    function nextStep() {
      currentStep = (currentStep + 1) % 3;
      updateUI();
    }

    function startTimer() {
      if (timer) clearInterval(timer);
      timer = setInterval(nextStep, 3500);
    }

    function togglePlay() {
      isPlaying = !isPlaying;
      document.getElementById('playBtn').textContent = isPlaying ? '⏸ Pause' : '▶ Play';
      if (isPlaying) {
        startTimer();
      } else {
        clearInterval(timer);
      }
    }

    startTimer();
  </script>
</body>
</html>

<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="UTF-8">
  <meta name="viewport" content="width=device-width, initial-scale=1.0">
  <title>Glomerular Hemodynamics & Obstruction</title>
  <style>
    * {
      box-sizing: border-box;
      margin: 0;
      padding: 0;
      font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;
    }

    body {
      background: transparent;
      color: #0f172a;
      padding: 10px;
      display: flex;
      flex-direction: column;
      align-items: center;
      justify-content: flex-start;
      min-height: 100%;
    }

    .container {
      width: 100%;
      max-width: 580px;
      display: flex;
      flex-direction: column;
      gap: 10px;
    }

    /* Tabs */
    .nav-tabs {
      display: flex;
      gap: 8px;
      width: 100%;
    }

    .tab-btn {
      flex: 1;
      padding: 8px 6px;
      font-size: 13px;
      font-weight: 600;
      text-align: center;
      background: #f1f5f9;
      border: 1px solid #cbd5e1;
      border-radius: 6px;
      cursor: pointer;
      color: #334155;
      transition: background-color 0.3s ease, color 0.3s ease, border-color 0.3s ease, box-shadow 0.3s ease;
    }

    .tab-btn:hover {
      background: #e2e8f0;
      color: #0f172a;
    }

    .tab-btn.active {
      background: #0284c7;
      color: #ffffff;
      border-color: #0284c7;
    }

    .tab-btn.danger-tab.active {
      background: #dc2626;
      border-color: #dc2626;
    }

    /* Diagram Stage without nested border frame */
    .diagram-stage {
      position: relative;
      width: 100%;
      height: 240px;
      background: #f8fafc;
      border-radius: 8px;
      overflow: hidden;
      display: flex;
      align-items: center;
      justify-content: center;
    }

    svg {
      width: 100%;
      height: 100%;
      overflow: visible;
    }

    /* Smooth animated transitions for vessels */
    #affVessel, #effVessel {
      transition: stroke-width 0.35s ease;
    }

    /* Smooth transitions for indicators */
    #filtrArrows, #backpressure, #stoneObj {
      transition: opacity 0.35s ease;
    }

    /* Calm non-flickering flow indicator */
    .flow-line {
      stroke-dasharray: 8 6;
      animation: slowFlow 3.5s linear infinite;
    }

    @keyframes slowFlow {
      to {
        stroke-dashoffset: -28;
      }
    }

    /* Calculation & Outcome Area - seamless blend */
    .info-footer {
      width: 100%;
      display: flex;
      flex-direction: column;
      gap: 8px;
      padding: 4px 2px;
    }

    .math-row {
      display: flex;
      align-items: center;
      justify-content: space-between;
      flex-wrap: wrap;
      gap: 6px;
      font-size: 13px;
      font-weight: 600;
      color: #334155;
    }

    .eq-group {
      display: inline-flex;
      align-items: center;
      gap: 4px;
      flex-wrap: wrap;
    }

    .val-badge {
      display: inline-flex;
      align-items: center;
      padding: 3px 7px;
      border-radius: 4px;
      font-size: 12px;
      font-weight: 700;
      line-height: 1;
      transition: background-color 0.3s ease, color 0.3s ease;
    }

    .badge-pgc { background: #fee2e2; color: #b91c1c; }
    .badge-pbs { background: #e0f2fe; color: #0369a1; }
    .badge-pi  { background: #fef3c7; color: #b45309; }
    .badge-nfp { background: #dcfce7; color: #15803d; }
    .badge-nfp.negative { background: #fee2e2; color: #dc2626; }

    .status-row {
      display: flex;
      align-items: center;
      justify-content: space-between;
      flex-wrap: wrap;
      gap: 4px;
      font-size: 13px;
      font-weight: 600;
    }

    .status-label {
      color: #475569;
    }

    .status-value {
      font-weight: 700;
      font-size: 13px;
      transition: color 0.3s ease;
    }

    @media (max-width: 440px) {
      .tab-btn {
        font-size: 11.5px;
        padding: 6px 3px;
      }
      .math-row, .status-row {
        font-size: 12px;
      }
      .val-badge {
        font-size: 11px;
        padding: 2px 5px;
      }
    }
  </style>
</head>
<body>

  <div class="container">
    <div class="nav-tabs" role="tablist">
      <button class="tab-btn active" id="tab0" onclick="selectScene(0)" role="tab" aria-selected="true">Afferent Constrict</button>
      <button class="tab-btn" id="tab1" onclick="selectScene(1)" role="tab" aria-selected="false">Efferent Constrict</button>
      <button class="tab-btn danger-tab" id="tab2" onclick="selectScene(2)" role="tab" aria-selected="false">Kidney Stone</button>
    </div>

    <div class="diagram-stage">
      <svg viewBox="0 0 540 240" id="diagSvg">
        <defs>
          <marker id="arr-red" markerWidth="6" markerHeight="6" refX="5" refY="3" orient="auto">
            <path d="M0,0 L6,3 L0,6 Z" fill="#ef4444" />
          </marker>
          <marker id="arr-blue" markerWidth="6" markerHeight="6" refX="5" refY="3" orient="auto">
            <path d="M0,0 L6,3 L0,6 Z" fill="#0284c7" />
          </marker>
          <marker id="arr-white" markerWidth="5" markerHeight="5" refX="4" refY="2.5" orient="auto">
            <path d="M0,0 L5,2.5 L0,5 Z" fill="#ffffff" />
          </marker>
        </defs>

        
        <path id="tubuleFluid" d="M 285 185 L 285 240" stroke="#bae6fd" stroke-width="26" stroke-linecap="square" fill="none" opacity="0.5" />
        <path id="bowmanOutline" d="M 270 48 C 185 48 180 180 265 185 C 305 185 305 215 305 240 L 265 240 C 265 200 240 195 235 180 C 160 165 165 68 270 68 Z" fill="#e0f2fe" stroke="#38bdf8" stroke-width="2.5" />

        
        <text x="75" y="34" font-size="12" font-weight="700" fill="#0284c7">Bowman's Capsule</text>
        <path d="M 182 32 L 196 46" stroke="#38bdf8" stroke-width="1.5" stroke-linecap="round" />

        
        <path id="affVessel" d="M 25 115 L 205 115" stroke="#ef4444" stroke-width="10" stroke-linecap="round" />
        <text x="75" y="78" font-size="13" font-weight="700" fill="#334155" id="affLabel">Afferent</text>
        <text x="75" y="93" font-size="11" font-weight="600" fill="#64748b" id="affSub">(Inflow)</text>

        
        <circle id="glomTuft" cx="245" cy="115" r="28" fill="#fee2e2" stroke="#dc2626" stroke-width="3" />
        <path d="M 230 105 Q 245 90 260 105 Q 245 130 230 115 Q 255 120 260 125" fill="none" stroke="#dc2626" stroke-width="3" stroke-linecap="round"/>

        
        <path id="effVessel" d="M 285 115 L 485 115" stroke="#ef4444" stroke-width="18" stroke-linecap="round" />
        <text x="385" y="78" font-size="13" font-weight="700" fill="#334155" id="effLabel">Efferent</text>
        <text x="385" y="93" font-size="11" font-weight="600" fill="#64748b" id="effSub">(Outflow)</text>

        
        <line id="flowIn" x1="45" y1="115" x2="185" y2="115" stroke="#ffffff" stroke-width="2.5" stroke-linecap="round" class="flow-line" marker-end="url(#arr-white)" />
        <line id="flowOut" x1="305" y1="115" x2="455" y2="115" stroke="#ffffff" stroke-width="2.5" stroke-linecap="round" class="flow-line" marker-end="url(#arr-white)" />

        
        <g id="filtrArrows">
          <path d="M 245 146 L 245 170" stroke="#0284c7" stroke-width="3" marker-end="url(#arr-blue)" />
          <path d="M 225 140 L 215 160" stroke="#0284c7" stroke-width="3" marker-end="url(#arr-blue)" />
          <path d="M 265 140 L 275 160" stroke="#0284c7" stroke-width="3" marker-end="url(#arr-blue)" />
          <text x="200" y="200" font-size="11" font-weight="700" fill="#0284c7">Filtration (GFR)</text>
        </g>

        
        <g id="backpressure" opacity="0">
          <path d="M 285 185 L 255 152" stroke="#dc2626" stroke-width="4" marker-end="url(#arr-red)" />
          <text x="145" y="165" font-size="12" font-weight="800" fill="#dc2626">P_BS Backpressure ⇑</text>
        </g>

        
        <g id="stoneObj" opacity="0">
          <polygon points="273,205 298,208 294,228 270,224" fill="#78350f" stroke="#451a03" stroke-width="2" />
          <text x="312" y="220" font-size="12" font-weight="800" fill="#9a3412">Stone 🛑</text>
          <text x="312" y="234" font-size="10.5" font-weight="600" fill="#b45309">Ureter Blocked</text>
        </g>

        
        
        <rect id="pgcBg" x="155" y="5" width="180" height="23" rx="6" fill="#fee2e2" stroke="#fca5a5" stroke-width="1" />
        <text id="pgcTag" x="245" y="21" text-anchor="middle" font-size="12" font-weight="800" fill="#b91c1c">P_GC: 45 mmHg (Low)</text>

        
        <text id="pbsTag" x="325" y="150" font-size="12.5" font-weight="800" fill="#0284c7">P_BS: 15 mmHg</text>
      </svg>
    </div>

    
    <div class="info-footer">
      <div class="math-row">
        <span>Net Filtration Formula:</span>
        <div class="eq-group" id="mathEq">
          <span>NFP =</span>
          <span class="val-badge badge-pgc" id="badgePgc">P_GC: 45</span>
          <span>-</span>
          <span class="val-badge badge-pbs" id="badgePbs">P_BS: 15</span>
          <span>-</span>
          <span class="val-badge badge-pi">π_GC: 30</span>
          <span>=</span>
          <span class="val-badge badge-nfp" id="nfpVal">0 mmHg</span>
        </div>
      </div>
      <div class="status-row">
        <span class="status-label">Clinical Effect:</span>
        <span class="status-value" id="gfrStatus" style="color: #d97706;">GFR Drops ↓ (Reduced Capillary Inflow)</span>
      </div>
    </div>
  </div>

  <script>
    const sceneData = [
      {
        affW: 8,
        effW: 18,
        pgcText: "P_GC: 45 mmHg (Low)",
        pgcVal: 45,
        pbsVal: 15,
        piVal: 30,
        nfp: 0,
        gfr: "GFR Drops ↓ (Reduced Capillary Inflow)",
        gfrColor: "#d97706",
        filtrOpacity: 0.25,
        stoneOpacity: 0,
        backOpacity: 0,
        affLabel: "Afferent (Constricted)",
        affSub: "Narrow Inflow",
        effLabel: "Efferent (Normal)",
        effSub: "Standard Outflow"
      },
      {
        affW: 22,
        effW: 7,
        pgcText: "P_GC: 65 mmHg (High)",
        pgcVal: 65,
        pbsVal: 15,
        piVal: 30,
        nfp: 20,
        gfr: "GFR Rises ↑ (Fluid Backs Up in Glomerulus)",
        gfrColor: "#16a34a",
        filtrOpacity: 1,
        stoneOpacity: 0,
        backOpacity: 0,
        affLabel: "Afferent (Normal/Wide)",
        affSub: "Open Inflow",
        effLabel: "Efferent (Constricted)",
        effSub: "Restricted Outflow"
      },
      {
        affW: 18,
        effW: 18,
        pgcText: "P_GC: 55 mmHg (Normal)",
        pgcVal: 55,
        pbsVal: 35,
        piVal: 30,
        nfp: -10,
        gfr: "Filtration Ceases 🛑 (NFP < 0 mmHg due to Stone)",
        gfrColor: "#dc2626",
        filtrOpacity: 0,
        stoneOpacity: 1,
        backOpacity: 1,
        affLabel: "Afferent (Normal)",
        affSub: "Normal Inflow",
        effLabel: "Efferent (Normal)",
        effSub: "Normal Outflow"
      }
    ];

    let autoTimer = null;

    function selectScene(idx, userInitiated = false) {
      if (userInitiated && autoTimer) {
        clearInterval(autoTimer);
        autoTimer = null;
      }

      // Update tabs
      for (let i = 0; i < 3; i++) {
        const btn = document.getElementById(`tab${i}`);
        const isActive = (i === idx);
        btn.classList.toggle('active', isActive);
        btn.setAttribute('aria-selected', isActive);
      }

      const d = sceneData[idx];

      // Update vessels with smooth animated transitions
      document.getElementById('affVessel').setAttribute('stroke-width', d.affW);
      document.getElementById('effVessel').setAttribute('stroke-width', d.effW);
      document.getElementById('affLabel').textContent = d.affLabel;
      document.getElementById('affSub').textContent = d.affSub;
      document.getElementById('effLabel').textContent = d.effLabel;
      document.getElementById('effSub').textContent = d.effSub;

      // Update pressure tags
      document.getElementById('pgcTag').textContent = d.pgcText;
      document.getElementById('pbsTag').textContent = `P_BS: ${d.pbsVal} mmHg`;

      // Update stone / filtration / backpressure opacities
      document.getElementById('filtrArrows').style.opacity = d.filtrOpacity;
      document.getElementById('stoneObj').style.opacity = d.stoneOpacity;
      document.getElementById('backpressure').style.opacity = d.backOpacity;

      // Update calculation formula
      const pgcBadge = document.getElementById('badgePgc');
      const pbsBadge = document.getElementById('badgePbs');
      const nfpBadge = document.getElementById('nfpVal');

      pgcBadge.textContent = `P_GC: ${d.pgcVal}`;
      pbsBadge.textContent = `P_BS: ${d.pbsVal}`;
      
      const nfpSign = d.nfp > 0 ? `+${d.nfp}` : `${d.nfp}`;
      nfpBadge.textContent = `${nfpSign} mmHg`;
      nfpBadge.className = `val-badge ${d.nfp <= 0 ? 'badge-nfp negative' : 'badge-nfp'}`;

      // Update outcome status
      const gfrStatus = document.getElementById('gfrStatus');
      gfrStatus.textContent = d.gfr;
      gfrStatus.style.color = d.gfrColor;
    }

    // Attach user click handlers
    document.querySelectorAll('.tab-btn').forEach((btn, index) => {
      btn.addEventListener('click', () => selectScene(index, true));
    });

    // Gentle auto-tour on initial launch
    let currentIdx = 0;
    autoTimer = setInterval(() => {
      currentIdx = (currentIdx + 1) % sceneData.length;
      selectScene(currentIdx, false);
    }, 4200);

    // Initial render
    selectScene(0);
  </script>
</body>
</html>

Tubular Reabsorption and Secretion in the Proximal and Distal Tubules

The Loop of Henle and Countercurrent Multiplication

Hormonal Control of Water and Sodium: ADH and RAAS Pathways

Hepatic Urea Cycle and Nitrogenous Waste Comparisons

Hemodialysis and Peritoneal Dialysis Technologies

science

Renal Physiology, Osmoregulation, and Waste Excretion

Regulacja osmotyczna — dlaczego zwierzęta muszą regulować gospodarkę wodno-solną

Regulacja osmotyczna w środowisku słodkowodnym

Regulacja osmotyczna w środowisku morskim

Regulacja osmotyczna w środowisku lądowym

Osmoregulacja u zwierząt

Istota procesu wydalania — definicja i znaczenie dla organizmu

Substancje wydalane z organizmu — przegląd

Wydalanie a defekacja — różnice między procesami

Amoniak jako produkt przemiany azotowej — zwierzęta wodne

Mocznik jako produkt przemiany azotowej — ssaki lądowe

Kwas moczowy jako produkt przemiany azotowej — ptaki, gady i owady

Środowisko życia a rodzaj wydalanego produktu azotowego — podsumowanie

Wydalanie u zwierząt — istota procesu i produkty azotowe

Układy wydalnicze bezkręgowców — protonefrydia

Układy wydalnicze bezkręgowców — metanefrydia

Układy wydalnicze bezkręgowców — kanaliki Malpighiego

Nerki kręgowców — przegląd budowy w poszczególnych grupach

Tendencje ewolucyjne w budowie kanalików wydalniczych zwierząt

Układy wydalnicze zwierząt — budowa i tendencje ewolucyjne

Cykl mocznikowy — istota procesu i znaczenie dla organizmu

Cykl mocznikowy — substraty i produkty analizowane na schemacie

Cykl mocznikowy — miejsce przebiegu i regulacja w wątrobie

Budowa nerki człowieka — kora, rdzeń i miedniczka nerkowa

Nefron jako jednostka funkcjonalna nerki — budowa

Kłębuszek nerkowy i torebka Bowmana — związek budowy z funkcją

Kanaliki nerkowe — związek budowy z funkcją

Drogi wyprowadzające mocz — moczowody, pęcherz i cewka moczowa

Związek budowy układu moczowego z funkcją — podsumowanie

Budowa układu moczowego i cykl mocznikowy

Filtracja kłębuszkowa — pierwszy etap tworzenia moczu

Resorpcja obwodowa — zwrot substancji użytecznych do krwi

Sekrecja obwodowa — wydzielanie substancji do moczu

Regulacja hormonalna tworzenia moczu — ADH (wazopresyna)

Regulacja hormonalna tworzenia moczu — aldosteron

Regulacja hormonalna tworzenia moczu — układ renina-angiotensyna-aldosteron (RAAS)

OGS.11.LS.HB.5

Aligned learning resources

Related diagrams